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Psychiatric hospitalization in
twins.
Koskenvuo M, Langinvainio H, Kaprio J,
Lonnqvist J, Tienari P.
Hospitalization rates of monozygotic
(MZ) and dizygotic (DZ) twin pairs in Finland were compared for
schizophrenia, neuroses, and alcoholism. Record-linkage of hospital
records and death certificates for the years 1972-1979 was carried out
for persons in the Finnish Twin Cohort (16,649 like-sexed twin pairs).
The ratio of the number of observed vs that of expected concordant pairs
and the ratio of concordance rates between MZ and DZ pairs were greater
among males than females, and greater among young (40 years old or less)
than among older pairs. The highest difference was found in
schizophrenia and the lowest in neuroses. Pairwise concordance rates for
schizophrenia (11.0% for MZ and 1.8% for DZ) seem to indicate great
environmental influence (high proportion of discordant pairs) with
apparent genetic liability (6.1-fold ratio in concordance between MZ and
DZ pairs). In neurotic disorders, the difference of pairwise concordance
rates between MZ and DZ pairs (6.8% vs 4.0%) was quite low, not strongly
supporting a genetic hypothesis. Of the MZ pairs concordant for
psychiatric hospitalization, 47% had lived together for their whole life
time; of those discordant, 16% lived together. The corresponding figures
for DZ pairs were 18% and 15%. The effect of intrapair relationships in
disease-concordant pairs should be taken into account when evaluating
the effect of genetic and environmental factors in psychiatric
disorders.
PMID: 6540965 [PubMed - indexed for MEDLINE]
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